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Does a fish hold the key to regenerating the heart after a heart attack?

Stem cell researchers use grants to study zebrafish's power to heal from cardiac injuries — and how early feathers form

Just as there are times when two heads are better than one, there are times when two labs are better than one. Thanks to the new Doerr Stem Cell Challenge Grants, teams of postdoctoral researchers from different USC labs have each received up to $10,000 in funding to pursue interdisciplinary one-year projects.

“The goal of the program is to stimulate new interdisciplinary stem cell research projects initiated and proposed by students and postdocs,” said Andrew McMahon, chair of the executive committee of USC Stem Cell. “This will enhance their creativity and independence, as well as their ability to compete for future grants supported by agencies such as the NIH.”

One winning team brings together two postdocs that work miles apart. Ang Li studies feather development in Cheng-Ming Chuong’s lab on the Health Sciences Campus and Yuwei Li researches imaging techniques in Scott Fraser’s lab on the University Park Campus.

Together, they will use pioneering imaging tools to study cell behavior during feather development. Specifically, they will monitor how cells move and organize in response to bioelectric cues or the electric currents that occur within all living organisms.

“When stem cells form an organ, there are two major issues, to differentiate into the right cell types and to be organized spatially,” said Chuong, professor of pathology and principal investigator with USC Stem Cell. “The issue of organization has not been studied as extensively as differentiation. This work, when accomplished, will be a major paper.”

Cardiac injuries

The other award went to a team of two postdocs in the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC: Lindsey Mork from Gage Crump’s lab and Michaela Patterson from Henry Sucov’s lab. They’ll use zebrafish to investigate the role of the Tnni3k gene in heart regeneration. When activated, this gene appears to lower the number of cells called mononuclear diploid cardiomyocytes, which form new cardiac muscle following an injury such as a heart attack.

The project combines the Sucov lab’s expertise in heart generation with the Crump lab’s knowledge of zebrafish, which have a remarkable ability to heal from severe cardiac injuries.

“In this project, Lindsey and Michaela directly address a fundamental question in regenerative biology: namely, the cellular basis for the profound differences in regenerative capacity between mammals and non-mammalian vertebrates such as the zebrafish,” said Crump, associate professor of stem cell biology and regenerative medicine.

Sucov — a professor of stem cell biology and regenerative medicine, cell and neurobiology, and biochemistry and molecular biology — added: “I have no doubts that they will uncover important new mechanisms fundamental to heart regeneration through this project, and their success could lead to a long-standing collaboration between the two labs.”

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Does a fish hold the key to regenerating the heart after a heart attack?

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