Like a smart sensor that adjusts the lighting in each room and a home’s overall temperature, a protein that governs the making of other proteins in the cell also appears capable of controlling fat levels in the body. The finding, which appeared in Cell Reports on Dec. 11, applies to the Maf1 protein in worms.
A version of the protein, which exists in humans, also regulates protein production in the cell, raising the possibility that it too may control fat storage. A protein with such a function would offer a new target for pharmaceuticals to regulate fat, said Sean Curran, assistant professor at the USC Davis School of Gerontology and the study’s corresponding author.
“We’ve known about Maf1 for over a decade, but so far people have only studied it in single cells, where it is known to regulate protein synthesis,” Curran said. “No one really looked at its effect on the whole organism before.”
It turns out that Maf1 plays a much more significant role in a whole animal: altering how the animal stores fat.
Curran and his colleagues tweaked the amount of Maf1 in C. elegans, a transparent worm often used as a model organism by biologists.
The team found that adding in a single extra copy of gene that expresses Maf1 decreased stored lipids by 34 percent, while reducing Maf1 levels increased stored lipids by 94 percent. And as expected from previous research, increased Maf1 lowered protein synthetic capacity while reduced Maf1 raised it.
Curran collaborated with USC graduate student Akshat Khanna and Deborah Johnson, formerly of the Keck School of Medicine of USC and now dean of the Graduate School of Biomedical Sciences at the Baylor College of Medicine.
It’s really exciting to find a completely new role for such a well-studied molecule.
“It’s really exciting to find a completely new role for such a well-studied molecule,” Khanna said.
Johnson published a related paper, released on the same day in PLoS Genetics, showing that Maf1 changes lipid metabolism in cancer cells, raising the possibility that it could be used in tumor cell suppression.
Next, Curran and his colleagues plan to explore whether the results hold true for mice and if so, plan to see whether they also do for humans.
The research was supported by the National Institutes of Health (grant numbers GM109028 and AG032308), the American Heart Association (14GRNT20280731), The Ellison Medical Foundation (AG-NS-0748-11) and the American Federation of Aging Research (002666-00001).