USC News

Menu Search

USC Has Two 2006 AACR Award Recipients

Two USC researchers are among the 11 recipients of the first Jeannik M. Littlefield-AACR Grants in Metastatic Colon Cancer Research from the American Association for Cancer Research (AACR).

USC was the only institution to have two award recipients from the international pool of 114 investigators.

The awards, of as much as $250,000, were established in February to support innovative research projects designed to accelerate the discovery and development of new agents to treat metastatic colon cancer. AACR is distributing a total of $2.64 million to the 11 awardees.

Robert D. Ladner, assistant professor of pathology, won an award for research that will explore new approaches to enhance the effectiveness of 5FU, the major chemotherapy utilized in colon cancer treatment.

Ladner has been collaborating with USC researcher Heinz Josef Lenz, professor of medicine in the division of oncology, and others to establish ways to increase its effectiveness.

Nouri Neamati, assistant professor of pharmaceutical sciences, won his award for “Preclinical Development of SC144 in Metastatic Colon Cancer.” A new agent, SC144 has been shown to cause up-regulation of IL24 � a very potent anticancer protein. SC144 will be fully evaluated in mouse models before trials will be extended to humans.

“My dream is to see a successful testing of this drug in colon cancer patients,” said Neamati, an expert in small-molecule drug design, “We are working very closely with Dr. Lenz, who has extensive expertise in clinical trials, on the translation of this drug and other related agents in patients.”

David Irwin, managing director of the Science and Education Division of the AACR, said, “Among the 114 applications submitted, these 11 awardees were judged to have the most merit. We offer our sincere congratulations to the investigators and anticipate they will make substantial contributions to this field of cancer research.”

The Jeannik M. Littlefield-AACR Grants in Metastatic Colon Cancer Research are sponsored by Jacques and Sandy Littlefield of Portola Valley, Calif., who donated $3 million to the AACR in late 2005. The grants are named for Jacques Littlefield’s mother.

USC Has Two 2006 AACR Award Recipients

Top stories on USC News