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Nanoscale explosives show potential in fight against cancer

The creation of Buckybombs could one day be used for demolition of cancer cells

Exploding buckyball. Bucky-Balls Turned Into Explosive Buckybombs.
Artist's rendering of an exploding Buckyball (USC/Holly Wilder)

In 1996, a trio of scientists won the Nobel Prize for Chemistry for their discovery of Buckminsterfullerene — soccer-ball-shaped spheres of 60 joined carbon atoms that exhibit special physical properties.

Now 20 years later, scientists have figured out how to turn them into Buckybombs.

 These nanoscale explosives show potential for use in fighting cancer, with the hope that they could one day target and eliminate cancer at the cellular level — triggering tiny explosions that kill cancer cells without affecting surrounding tissue.

“Future applications would probably use other types of carbon structures — such as carbon nanotubes, but we started with Bucky-balls because they’re very stable and a lot is known about them,” said Oleg Prezhdo, professor of chemistry at the USC Dornsife College of Letters, Arts and Sciences and corresponding author of a paper on the explosives that was published in The Journal of Physical Chemistry on Feb. 24.

Laser targets nanotubes

Carbon nanotubes, close relatives of Bucky-balls, are used already to treat cancer. They can be accumulated in cancer cells and heated up by a laser, which penetrates through surrounding tissues without affecting them and directly targets carbon nanotubes. Modifying carbon nanotubes the same way as the Buckybombs will make the cancer treatment more efficient — reducing the amount of treatment needed, Prezhdo said.

To build the miniature explosives, Prezhdo and his colleagues attached 12 nitrous oxide molecules to a single Bucky-ball and then heated it. Within picoseconds, the Bucky-ball disintegrated — increasing temperature by thousands of degrees in a controlled explosion.

The source of the explosion’s power is the breaking of powerful carbon bonds, which snap apart to bond with oxygen from the nitrous oxide, resulting in the creation of carbon dioxide, Prezhdo said.

Prezhdo collaborated with co-corresponding author Vitaly Chaban, who was at USC when the research was completed and is now at the Universidade Federal de São Paulo in Brazil with fellow co-corresponding author Eudes Eterno Fileti.

The research was funded by the São Paulo Research Foundation, the Brazilian National Council for Scientific and Technological Development, the U.S. Department of Energy (grant DE-SC0006527) and the Russian Science Foundation (project No. 14-43-00052).

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Nanoscale explosives show potential in fight against cancer

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