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Motor control development may extend into late adolescence, study finds

Perkins_Robertby Robert Perkins
Francisco Valero-Cuevas invented a tool that allows for more precise measurement of fine motor control in humans. (Photo/Evan-Amos)
Francisco Valero-Cuevas invented a tool that allows for more precise measurement of fine motor control in humans. (Photo/Evan-Amos)

The development of fine motor control — the ability to use your fingertips to manipulate objects — takes longer than previously believed and isn’t entirely the result of brain development, according to a pair of complementary studies by USC researchers.

The studies open up the potential to use therapy to continue improving the motor control skills of children suffering from neurodevelopmental disorders such as cerebral palsy, a blanket term for central motor disorders that affects about 764,000 children and adults nationwide

“These findings show that it’s not only possible but critical to continue or begin physical therapy in adolescence,” said Francisco Valero-Cuevas, corresponding author of the studies that will appear in the Journal of Neurophysiology and The Journal of Neuroscience, two leading publications in the field.

“We find we likely do not have a narrow window of opportunity in early childhood to improve manipulation skills, as previously believed, but rather developmental plasticity lasts much longer and provides opportunity throughout adolescence,” he said. “This complements similarly exciting findings showing brain plasticity in adulthood and old age.”

Researchers had previously been able to detect improvements in fine motor control of the hand only until around age 8 to 10; however, Valero-Cuevas — a professor of biomedical engineering at the USC Viterbi School of Engineering and biokinesiology and physical therapy at the Ostrow School of Dentistry of USC — invented a tool that allows for more precise measurement of fine motor control.

The tool is simple: springs of varying stiffness and length set between plastic pads, which he’s patented. Motor skill is then determined by the individual’s ability to compress the increasingly awkward spring devices. Sudarshan Dayanidhi, during his PhD studies at USC with Valero-Cuevas, developed and applied clinically useful versions of this technology with great success.

With this new mechanism, and in collaboration with Åsa Hedberg and Hans Forssberg of the Astrid Lindgren Children’s Hospital in Stockholm, they tested 130 children with typical development between 4 and 16 years of age, and demonstrated that even the 16-year-olds were continuing to hone their fine motor skills. Their findings will appear in the Journal of Neurophysiology on Oct. 1.

To further this study, Dayanidhi and Valero-Cuevas teamed up with Jason Kutch, assistant professor of biokinesiology and physical therapy at USC, to explore whether this longer developmental timeline for dexterity was tied not just to brain maturation but also to muscular development.

It has long been thought that improved dexterity involved only brain development and muscle growth — where muscles only got bigger and stronger but didn’t add to dexterous skills since they are performed at low forces. The research by Dayanidhi, Kutch and Valero-Cuevas indicated otherwise.

“Combining our metrics of dexterity from Dayanidhi’s PhD work, with novel and noninvasive measures of muscle contraction time developed by Professor Kutch, we were able to show a previously unknown strong association between gains in dexterity with improvement in low-force muscle contraction time,” Valero-Cuevas said.

This second facet of the research showing how both dexterity and muscle function improve in children will appear in The Journal of Neuroscience on Sept. 18.

Research was funded in part by the National Science Foundation (grant EFRI-COPN 0237258), the National Institute on Disability and Rehabilitation (Research grant RERC 84-133E2008-8) and the National Institutes of Health (grants R21-HD-048566, R01-AR-050520 and R01-AR-052345).

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